Neutral and weakly nonneutral sequence variants may define individuality
نویسندگان
چکیده
منابع مشابه
Specificity in transmembrane helix-helix interactions can define a hierarchy of stability for sequence variants.
The folding, stability, and oligomerization of helical membrane proteins depend in part on a precise set of packing interactions between transmembrane helices. To understand the energetic principles of these helix-helix interactions, we have used alanine-scanning mutagenesis and sedimentation equilibrium analytical ultracentrifugation to quantitatively examine the sequence dependence of the gly...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2013
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1216613110